Irisin,Fc, Recombinant, Human (Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2, FNDC5)

Size

£358.00

SKU:: 044962
Molecular Weight:: 50
Purity:: ≥95% (SDS-PAGE) Endotoxin: ≤0.1EU/ug (LAL)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder from PBS. Reconstitute with 100ul dH2O. Further dilutions can be made in PBS, >0.1% BSA.
Extra Details:: Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. AA Sequence: aa16-127 of human Irisin fused at the C-terminus to the Fc portion of human IgG1. Species Homology: aa16-127 of human Irisin corresponds to aa29-140 of mouse Irisin. Irisin has 100% identity betwen mouse, rat, monkey and human. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Further dilutions can be made in PBS, >0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.