IL-38, Recombinant, Human, His-Tag (Interleukin-1 Family Member 10 theta, IL-1F10, FIL1 theta, FKSG75, IL-1HY2, IL1-theta, Interleukin-1 HY2, Interleukin-1 Receptor Antagonist FKSG75)

Size

£466.00

SKU:: 044948
Molecular Weight:: 18
Purity:: ≥95% (SDS-PAGE) Endotoxin: ≤0.01EU/ug protein (LAL)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder from 50mM Tris-Cl, pH 8.0, 150mM sodium chloride. Reconstitute with 100ul sterile ddH2O
Extra Details:: IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36α, IL-36β or IL-36γ) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. Amino Acid Sequence: Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag. Swiss/UniProt Accession: Q8WWZ1 Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice