IL-23, Recombinant, Human, FLAG-Tag (Interleukin-23)

Size

£512.00

SKU:: 044912
Molecular Weight:: 70
Purity:: ≥95% (SDS-PAGE). Endotoxin: ≤0.06EU/ug (LAL test; Lonza).
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with sterile ddH2O. PBS containing at least 0.1% BSA should be used for further dilutions.
Extra Details:: Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis. Sequence: Human IL-12p40 peptide (aa23-328) is fused at the C-terminus to a 18aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the IL-23p19 peptide (aa20-189) and fused at the N-terminus to a FLAG-Tag. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice