IBMX (3-Isobutyl 1-methylxanthine, NSC 165960, SC2964, EINECS 249-259-3)

Size

£289.00

SKU:: 044890
Molecular Weight:: 222.3
Purity:: ≥99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 28822-58-4
Format:: Supplied as a white solid.
Extra Details:: Cell permeable, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor. Increases cAMP levels that activate PKA, leading to decreased proliferation, increased differentiation and induction of apoptosis. Enhances differentiation of 3T3-L1 cells. Non-selective adenosine receptor antagonist. Inhibits Ca2+ ion channels. Activates TNF-alpha. Adipogenic. Activates leukotriene synthesis. Reduces inflammation and innate immunity. IC50 values are 13, 18, 19, 32 and 50uM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively Solubility: DMSO, Dichloromethane, Ether, Ethyl acetate, Methanol and ethanol. Insoluble in water. Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 2 years after receipt when stored at -20°C.