Flagellin (FliC) 95+%

Size

£397.00

SKU:: 044816
Purity:: ≥95% (SDS-PAGE) Endotoxin: <0.01EU/ug (LAL test; Lonza)
Storage Conditions:: 4°C/-20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
Extra Details:: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system. Biological Activity: Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.