FGF-23,Fc, Recombinant, Human (Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor)

Size

£390.00

SKU:: 044812
Molecular Weight:: 60
Purity:: >90% (SDS-PAGE)
Storage Conditions:: 4°C/-20°C
Supplier:: United States Biological
Format:: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
Extra Details:: FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC). Biological Activity: Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Sequence: Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to the Fc portion of human IgG1. Molecular Weight: ~60kD (SDS-PAGE, full-length) FGF23 is cleaved between arg179 and ser 180 (~40kD). Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Working aliquots are stable for up to 3 months when stored at -20°C.