DR6, Recombinant, Mouse, Fc Fusion (Human IgG1) (Death Receptor 6, Tumor Necrosis Factor Receptor Superfamily Member 21, TNFRSF21)

Size

£428.00

SKU:: 044765
Molecular Weight:: 80
Purity:: ≥95% (SDS-PAGE). Endotoxin: ≤0.1EU/ug (LAL).
Storage Conditions:: 4°C/-20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, pH 7.2. Reconstitute with 50ul sterile ddH2O.
Extra Details:: DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6. Recombinant protein corresponding to aa42-348 from mouse DR6, fused at the C-terminus to the Fc portion of human IgG1, expressed in HEK293 cells. Uniprot Accession: Q9EPU5 Molecular Weight: ~80kD (SDS-PAGE) Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.