CD137L, Soluble, Recombinant, Mouse (4-1BBL, TNFSF9)

Size

£607.00

SKU:: 044652
Molecular Weight:: 40
Purity:: ≥95% (SDS-PAGE). Endotoxin: ≤0.01EU/ug (LAL).
Storage Conditions:: 4°C/-20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute with 50ul sterile ddH2O.
Extra Details:: The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response. The extracellular domain of mouse CD137L (aa104-309) is fused at the N-terminus to a FLAG®-tag, expressed in HEK293 cells. Molecular Weight: ~40kD (SDS-PAGE) Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.