CD137, Recombinant, Mouse,Fc (4-1BB, TNFRSF9)

Size

£512.00

SKU:: 044647
Molecular Weight:: 50
Purity:: ≥95% (SDS-PAGE). Endotoxin: <0.1EU/ug (LAL test; Lonza).
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a 0.2um filtered solution in PBS.
Extra Details:: CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice. Sequence: The extracellular domain of mouse CD137 (aa1-185) is fused at the C-terminus to the Fc portion of human IgG1. Molecular Weight: ~50kD (SDS-PAGE) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.