UPF2, ID (UPF2, KIAA1408, RENT2, Regulator of nonsense transcripts 2, Nonsense mRNA reducing factor 2, Up-frameshift suppressor 2 homolog)

Size

£696.00

SKU:: 043629
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: UPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the Central region of human UPF2.
Format:: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Extra Details:: UPF2 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Applications: Suitable for use in Western Blot, Indirect Flow Cytometry, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Indirect Flow Cytometry: 1:10-50 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.