GAD2 (GAD2, GAD65, Glutamate decarboxylase 2, 65kD glutamic acid decarboxylase, Glutamate decarboxylase 65kD isoform)

Size

£633.00

SKU:: 030979
Purity:: Ascites
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 109-138 of human GAD2. Species Sequence Homology: mouse and porcine
Clone:: 458CT17.2.4
Format:: Supplied as a liquid, 0.09% sodium azide.
Extra Details:: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. Applications: Suitable for use in Western Blot and ELISA.. Other applications not tested. Recommended Dilutions: Western Blot: 1:100-1:1600 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.