PPM1A

Size

£652.00

SKU:: 030557
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. coli.
Clone:: 13B635
Format:: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.
Extra Details:: The protein encoded by this gene is a member of the PP2C family of Ser:Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53:p53, which leads to G2:M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. Applications: Western Blot: 1:500-1:2000 Flow Cytometry: 1:200-1:400 ELISA: 1:10000 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.