IGF2BP3 (Insulin-like Growth Factor 2 mRNA-binding Protein 3, IGF2 mRNA-binding Protein 3, IMP-3, IGF-II mRNA-binding Protein 3, KH Domain-containing Protein Overexpressed in Cancer, hKOC, VICKZ Family Member 3, IMP3, KOC1, VICKZ3) (RIP Validated Antibody and Primer Set)

Size

£997.00

SKU:: 029512
Purity:: Purified by affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: KLH-conjugated linear peptide corresponding to human IGF2 mRNA-binding protein 3 at and around the C-terminus. Species sequence homology: Chimpanzee, rhesus monkey, canine, equine (100%).
Format:: Supplied as a liquid in PBS, 0.09% sodium azide, 30% glycerol.
Extra Details:: The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. Applications: Suitable for use in Western Blot, Immunoprecipitation and RNA Binding Protein Immunoprecipitation assay. Other applications not tested. Recommended Dilution: RIP: ~5ug/RIP Optimal dilutions to be determined by the researcher. Positive Control: Includes negative control normal rabbit IgG antibody and control primers specific for the cDNA of human IGF2. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice