Vemurafenib, Free Base (PLX4032)

Size

£216.00

SKU:: 022761
Molecular Weight:: 489.92
Purity:: ≥99% (HPLC), ≥99% (TLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 918504-65-1
Format:: Cyrstalline solid
Extra Details:: Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Appearance: Cyrstalline solid Purity: ≥99% (HPLC) ≥99% (TLC) Melting Point: 269-270.5°C Method for Determining Identity: Proton NMR (CD3OD and DMSO-d6), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis Solubility: Soluble in DMSO at 100mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility Storage: Store at or below -20ºC. Note: As of September 2011 the current correct CAS number for vemurafenib, also known as PLX4032, is given above. Chemical Abstracts Service recently canceled another CAS number, 1029872-54-5, that had previously been used for vemurafenib under its older name, PLX4032. However, this canceled number remains in wide use and receives the vast majority of hits on Google.