Tamoxifen

Size

£377.00

SKU:: 021245
Molecular Weight:: 371.52
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 10540-29-1
Extra Details:: Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. Synonyms: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; Mammaton; Novaldex; Tamoxifen; Z-Tamoxifen CAS No: 10540-29-1 Molecular Formula: C₂₆H₂₉NO Molecular Weight: 371.52 Purity (HPLC): ≥98% Appearance: White to off-white powder 1H-NMR: Conforms to structure Melting Point: >92°C (dec.) (lit) Storage and Stability: Store at -20°C. Stable for 12 months after receipt.