019859
Ponatinib, Free Base (AP24534)
Size
£146.00
- SKU:
- 019859
- Molecular Weight:
- 532.56
- Purity:
- ≥99% (HPLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 943319-70-8
- Format:
- White to off-white powder
- Extra Details:
- Ponatinib is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors. Ponatinib is the active ingredient in the drug product sold under the trade name Iclusig®, currently approved in at least one country for use in patients with chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia. Synonyms: 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide; AP 24534; Iclusig CAS No: 943319-70-8 HCl salt: 114544-31-8 Molecular Formula: C29H27F3N6O Molecular Weight: 532.56 Appearance White to off-white powder Purity: ≥99% (HPLC) Melting Point: >160°C (dec.) Solubility: Soluble in DMSO at 50 mg/mL; soluble in ethanol at 25 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive. Store under inert atmosphere.
- Shipping Conditions:
- Ambient