Methicillin Sodium, USP

Size

£122.00

SKU:: 016110
Molecular Weight:: 402.4
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 132-92-3
Format:: Supplied as a white to off-white powder.
Extra Details:: Methicillin sodium is a narrow spectrum β-lactam antibiotic related to Penicillin. β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Methicillin is mostly resistant to β-lactamases. Methicillin targets primarily the cell wall of Gram positive organisms especially Staphylococcus aureus. Water (Karl Fisher): ≤10% Melting Point: 196197°C Optical Rotation: +225° Solubility: Water: ~0.3mg/ml Acetone: 0.35mg/ml Ethanol: 40mg/ml MIC: Staphylococcus aureus: 0.5ug/ml-32ug/ml Storage: -20°C