3-epi-25-Hydroxy Vitamin D3

Size

£1,221.00

SKU:: 014649
Molecular Weight:: 406.67
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: White to Off-White Solid
Extra Details:: The labeled epimer metabolite of Calcifediol or 25-hydroxyvitamin D3. Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D),[1] is a prehormone that is produced in the liver by hydroxylation of vitamin D3(cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. Physicians worldwide measure this metabolite to determine a patient's vitamin D status.[2] At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days.[3] Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.[4][5] Form: White to Off-White Solid Melting Point: 60-62°C Solubility: Chloroform, Methanol