FTY720 Hydrochloride

Size

£364.00

SKU:: 012651
Molecular Weight:: 343.93
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 162359-56-0
Format:: White Solid
Extra Details:: FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). Form: White Solid Melting Point: 102-107°C Solubility: DMSO, Ethanol, Methanol