CHIR-99021 Hydrochloride

Size

£453.00

SKU:: 006005
Molecular Weight:: 501.8
Purity:: ~90%
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 1797989-42-4
Format:: Supplied as a pale beige solid
Extra Details:: CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Synonyms: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride CAS No: 1797989-42-4 Molecular Formula: C22H19Cl3N8 Molecular Weight: 501.80 Appearance: Supplied as a pale beige solid Purity: ~90% Atmoshpere: Inert gas Melting Point: >238°C (dec) Solubility: DMSO (slightly), Methanol (slightly) Method for Determining Identity: Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: SiO2; Dichloromethane : Methanol : Ammonium Hydroxide = 9 : 1 : 0.1; Visualized with UV and AMCS; Single spot, Rf=0.40. Chloride Content: As reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.