2-Acetyl-6-(dimethylamino)naphthalene (2-ADN)

Size

£377.00

SKU:: 001269
Molecular Weight:: 213.28
Purity:: ≥98%
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 68520-00-3
Format:: Light yellow to yellow solid
Extra Details:: 2-Acetyl-6-(dimethylamino)naphthalene (2-ADN) is a fluorescent probe that has been shown to react with nucleic acids. 2-ADN is an acyl chain analog of the natural substrate, naphthoquinone. 2-ADN reacts with dsDNA and RNA by intercalating between the bases in the DNA duplex or RNA strand and then reacting with the nucleobases at the ends of each strand to form a covalent bond. The reaction rate can be increased by increasing the length of the acyl chain. In vitro studies have shown that 2-ADN binds preferentially to euchromatin regions of chromosomes, which are regions rich in gene activity. Fluorescence assays have also shown that 2-ADN binds to wild type strains more efficiently than mutant strains. Synonyms: 1-[6-(Dimethylamino)-2-naphthalenyl]-ethanone; 1-(6-Dimethylaminonaphthalen-2-yl)ethanone; Acdan; Acedan; 2-ADN CAS No: 68520-00-3 Molecular Formula: C₁₄H₁₅NO Molecular Weight: 213.28 Appearance: Light yellow to yellow solid Purity: ≥98% Melting Point: 149-153°C Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly, Sonicated) Storage and Stability: Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.