691642
anti-C. difficile ToxinA, EBS-I-100, mouse monoclonal antibody
Cannot supply to this region.
- SKU:
- 691642
- Application:
- ELISA, IHC, IF, ICC
- Concentration:
- 100 ug/ml
- Species Reactivity:
- Bacteria
- Purification:
- Affinity Purified
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Host:
- Mouse
- Reactivities:
- Bacteria
- ABP:
- No Import Docs
- Immunogen:
- C. difficile toxin A
- Formulation:
- PBS with 0.02% sodium azide
- Clone:
- EBS-I-100
- Extra Details:
- EBS-I-100 reacts with C. difficile Toxin A, but not with V. cholerae subunit a, V. cholerae toxin, Pseudomonas aeruginosa exotoxin A, H-LT and P-LT. C. difficile is a major nosocomial pathogen that causes antibiotic-associated colitis and mediates inflammatory diarrhea by releasing two large protein enterotoxins (toxin A and toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. C. difficile toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. C. difficile toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation. Positive control: Clostridium difficile extract or infected cells or tissue.
- Shipping Conditions:
- Blue Ice