691626
anti-NuMA, EBS-C-002, mouse monoclonal antibody
Cannot supply to this region.
- SKU:
- 691626
- Additional Names:
- Nuclear mitotic apparatus protein 1, Nuclear matrix protein-22, NMP-22, Nuclear mitotic apparatus protein, NuMA protein, SP-H antigen, NUMA1, NMP22, NUMA
- Application:
- ELISA, IHC, WB
- Concentration:
- 100 ug/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Host:
- Mouse
- Reactivities:
- Human
- ABP:
- No Import Docs
- Immunogen:
- Live Ls 174T cells (colon carcinoma)
- Formulation:
- PBS with 0.02% sodium azide
- Clone:
- EBS-C-002
- Uniprot:
- Q14980
- Synonyms:
- centrophilin stabilizes mitotic spindle in mitotic cells;NMP-22;nuclear matrix protein-22;Nuclear mitotic apparatus protein;nuclear mitotic apparatus protein 1;NUMA;SP-H antigen;structural nuclear protein
- Extra Details:
- EBS-C-002 reacts with NuMA or Nuclear Mitotic Apparatus protein, which at the onset of mitosis redistributes from the nucleus to two centrosomal structures at the poles of the mitotic spindle, where it plays a vital role in establishing and maintaining its bipolar structure. After anaphase the protein redistributes from the spindle polar region into the reforming nucleus and concentrates initially at the site where nuclear lamins and perichomatin have been reported to assemble. In contrast to mitotic cells, post-mitotic neurons display NuMA both in the nucleus and in the cytoplasm. Due to release from dead cells, NuMA is also used as oncological marker in serum and urine. In addition, chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia. Positive control: human toncil.
- Shipping Conditions:
- Blue Ice