691532
anti-UACA, AE-5, mouse monoclonal antibody
Cannot supply to this region.
- SKU:
- 691532
- Additional Names:
- Uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA, KIAA1561
- Application:
- Flow Cytometry, IHC, WB, IF, ICC
- Concentration:
- 100 ug/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Progen
- Host:
- Mouse
- Reactivities:
- Human, Mouse
- ABP:
- No Import Docs
- Immunogen:
- Nuclei of myeloid leukemia biopsy cells
- Formulation:
- PBS with 0.02% sodium azide
- Clone:
- AE-5
- Uniprot:
- Q8CGB3, Q9BZF9
- Synonyms:
- 2700059D02Rik;nuc;nuclear membrane binding protein;nuclear membrane binding protein NUCLING;nuclear membrane-binding protein;NUCLING;uveal autoantigen with coiled-coil domains and ankyrin repeats
- Extra Details:
- UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, a mRNA differentially expressed in F9 embryonal carcinoma cells, and that it is up-regulated during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway. Positive control: HeLa or 293T cells. Highly expressed in skeletal muscle, heart, kidney and pancreas. Also expressed in epidermal melanocytes, eye muscles and thyroid follicular cells.
- Shipping Conditions:
- Blue Ice