ICH5016
Atibuclimab Biosimilar - Research Grade
Cannot supply to this region.
- SKU:
- ICH5016
- Additional Names:
- cluster of differentiation 14
- Application:
- FuncS
- Concentration:
- 5mg/ml
- Species Reactivity:
- Human
- Purity:
- >95% by SDS-PAGE
- Purification:
- This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- Storage Conditions:
- This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
- Supplier:
- Ichor Bio
- Reactivities:
- Human
- ABP:
- No Import Docs
- Formulation:
- Sterile, preservative-free, solution in PBS. BSA and Azide free.
- Uniprot:
- P08571
- Extra Details:
- RUO atibuclimab is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra.
- Shipping Conditions:
- Blue Ice
