ICH1189
Bulk Anti-Human CD18 (IB4) Antibody
Cannot supply to this region.
- SKU:
- ICH1189
- Additional Names:
- Integrin beta-2, integrin beta chain, beta 2, ITGB2
- Application:
- Flow Cytometry, IF, FuncS
- Concentration:
- ≥ 2.0 mg/ml
- Species Reactivity:
- Human
- Purity:
- >95% by SDS-PAGE
- Purification:
- This monoclonal antibody was purified using Protein A
- Storage Conditions:
- This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- Ichor Bio
- Host:
- Mouse
- Reactivities:
- Human
- ABP:
- No Import Docs
- Formulation:
- Sterile, preservative-free, solution in PBS. BSA and Azide free.
- Clone:
- 1B4
- Extra Details:
- Murine (m) 1B4 was humanized (h) by the CDR-grafting method to create an anti-CD18 antibody with similar avidity, specificity, and efficacy as the murine antibody. In rhesus monkeys, h1B4 is less immunogenic than m1B4 and elicits only anti-idiotypic antibodies. Additionally, h1B4 and m1B4 exhibit equivalent staining specificity and intensity in rabbit bone marrow leukocytes. For humanization, human VH and VL FR were chosen based on high identity with their corresponding m1B4 FR3. Once grafted with the m1B4 CDR, the human VH and VL FR were expressed as fusion proteins with the IgG4 and Cκ human constant regions, respectively. The h1B4 monoclonal antibody has been used in multiple studies of adhesion in different model systems and to measure the expression of CD18 in B-ALL cell lines.
- Shipping Conditions:
- Blue Ice
