Vanoxonin, Thymidylate Synthase Inhibitor

Size

£650.00

SKU:: 10744
Storage Conditions:: -20[o]C
Supplier:: Funakoshi
CAS Number:: 86933-99-5
Extra Details:: M.W.: 427.41 Purity : > 80％ (HPLC) Molecular Formula : C18H25N3O9 Solubility : Soluble in MeOH, DMSO, Acetic acid, and H2O, Insoluble : EtOAc, Chloroform, and n-hexane. Vanoxonin is a natural product delivered from cell culture of Saccharopolyspora hirsuta MG245-CF2 as an inhibitor of thymidylate synthetase. Vanoxonin forms a complex with a vanadium (V5+) which exhibits a strong inhibition against the synthetase. Howeber, Vanoxonin alone shows weak inhibition (IC50: 200 µg/mL). Vanoxonin-V5+ complex also showed in vitro cytotoxic activity against L-1210 lymphatic leukemia cells (MIC: 25 μg/mL).