100-222AF
Recombinant Animal-Free Human IL-2(C126S)
Size
£133.00
- SKU:
- 100-222AF
- Additional Names:
- T cell growth factor, TCGF, Aldesleukin
- Molecular Weight:
- 15.5
- Purity:
- ≥97
- Source:
- E.coli
- Storage Conditions:
- Sterile 10 mM HCl at 0.1 mg/mL
- Supplier:
- FujiFilm Irvine Scientific
- Formulation:
- 0.1% Trifluoroacetic Acid (TFA)
- Format:
- Lyophilized from a 0.2 µm filtered solution
- Species:
- Recombinant Human
- Uniprot:
- P60568
- Extra Details:
- IL-2C126S, an immune-regulating cytokine originating from lymphocytes, operates via the IL-2R receptor to trigger the expansion of activated T cells and encourage T cell maturation (1). IL-2 mediates its action by binding to IL-2 receptors (IL-2R), consisting of either trimeric receptors made of IL-2Rα (CD25), IL-2Rβ (CD122), and IL-2Rγ (γc, CD132) chains or dimeric βγ IL-2Rs (2). This cytokine also facilitates the growth and differentiation of B cells, natural killer (NK) cells, monocytes, and macrophages (3). Moreover, it plays a role in promoting the proliferation and differentiation of CAR T cells, T cells, and NK cells. In addition, IL-2 stimulates the activation and amplification of T cells and NK cells derived from peripheral blood (4).
- Shipping Conditions:
- Ambient