100-220
Recombinant Human IL-34
Size
£243.00
- SKU:
- 100-220
- Additional Names:
- None
- Molecular Weight:
- 26
- Purity:
- ≥95
- Source:
- CHO cells
- Storage Conditions:
- Sterile water at 0.1 mg/mL (reconstitution at concentrations > 0.1 mg/mL may result in a precipitate)
- Supplier:
- FujiFilm Irvine Scientific
- Formulation:
- Phosphate Buffered Saline (PBS)
- Format:
- Lyophilized from a 0.2 µm filtered solution
- Species:
- Recombinant Human
- Uniprot:
- NP_689669
- Extra Details:
- Interleukin 34 (IL-34) was originally identified in humans, by large scale screening of secreted proteins; orthologs have also been found in chimpanzee, murine, rat and chicken. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. IL-34 is secreted as a homodimer and contains one potential N-glycosylation site. IL-34 increases proliferation of immune cells known as monocytes; it elicits its activity by binding the Colony Stimulating Factor 1 Receptor (CSF-1R). Expression of IL-34 is most abundant in the spleen and is expressed in many other tissues including the heart, brain, liver, kidney, thymus, intestine and lung. Human IL-34 contains a C-terminal 6x-polyhistidine (6xHis) tag.
- Shipping Conditions:
- Ambient