100-208
Recombinant Human R-SPONDIN-1
Size
£111.00
- SKU:
- 100-208
- Additional Names:
- hRspo1, Roof plate-specific spondin-1
- Molecular Weight:
- 26.8
- Purity:
- ≥95
- Source:
- CHO cells
- Storage Conditions:
- Sterile water at 0.1 mg/mL
- Supplier:
- FujiFilm Irvine Scientific
- Formulation:
- Phosphate Buffered Saline (PBS)
- Format:
- Lyophilized from a 0.2 µm filtered solution
- Species:
- Recombinant Human
- Uniprot:
- Q2MKA7
- Extra Details:
- R-Spondin-1 (RSPO-1) is a secreted growth factor that stabilizes β-catenin and enhances WNT signaling. RSPO-1 is expressed in many tissues and regulates female sex determination, XX gonad development, oocyte differentiation, and hematopoietic stem cell specification. The RSPO-1 stabilization of β-catenin promotes intestinal crypt cell proliferation. This suggests that RSPO-1 functions as a stem cell growth factor and may have therapeutic potential in the treatment of gastrointestinal diseases and chemotherapy-induced intestinal mucositis. Additionally, recombinant RSPO-1 protein is used to initiate and maintain intestinal organoid cultures.
- Shipping Conditions:
- Ambient