100-161
Recombinant Human IL-17AF Heterodimer
Size
£111.00
- SKU:
- 100-161
- Additional Names:
- None
- Molecular Weight:
- /30.7
- Purity:
- ≥95
- Source:
- E.coli
- Storage Conditions:
- Sterile water at 0.1 mg/mL
- Supplier:
- FujiFilm Irvine Scientific
- Formulation:
- 0.1% Trifluoroacetic Acid (TFA)
- Format:
- Lyophilized from a 0.2 µm filtered solution
- Species:
- Recombinant Human
- Uniprot:
- Q16552/Q96PD4
- Extra Details:
- Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells.
- Shipping Conditions:
- Ambient