10-7305
Intelliscreen[TM] Wnt/B Beta-catenin (canonical) Mini-Library
Size
£533.00
- SKU:
- 10-7305
- Physical State:
- Supplied as DMSO solution @ 10mM
- Storage Conditions:
- -70[o]C
- Supplier:
- Focus Biomolecules
- Immunogen:
- Chemical Library|Transcription factor
- Extra Details:
- The Wnt/B Beta-catenin pathway is a multi-component pathway primarily involved in embryonic development, adult tissue homeostasis, and cell proliferation. Wnt proteins (i.e Wnt1, Wnt3a, Wnt5a) mediate extracellular signals that activate Wnt membrane receptors Frizzled and LRP5/6. Once activated, these signals inactivate a B Beta-catenin degradation complex allowing B Beta-catenin to translocate to the nucleus where it binds to TCF enabling target gene transcription. Dysfunction in the Wnt/B Beta-catenin pathway is implicated in various cancers, liver disease, ALS, Alzheimer's disease, bone disease, and cardiovascular disease.
- Shipping Conditions:
- Dry Ice