10-5885
ONX-0914
Size
£150.00
- SKU:
- 10-5885
- Additional Names:
- PR-957
- Physical State:
- Solid
- Molecular Weight:
- 580.68
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 960374-59-8
- Immunogen:
- Proteasome
- Extra Details:
- ONX-0914 (960374-59-8) is a selective inhibitor of the LMP7 subunit of the immunoproteasome (IC50 = 65 nM for mouse) which is the chymotrypsin-like subunit.1 Treatment with ONX-0914 resulted in suppression of Th1 and Th17 cells but enhancement of regulatory T cell differentiation in mouse models of induced colitis.2 ONX-0914 retards rheumatoid arthritis progression3, ameliorates diabetic cardiomyopathy4 and attenuates atherosclerosis and metabolic syndrome in mice5.
- Shipping Conditions:
- Ambient