10-5713
Lactoyl phenylalanine
Size
£173.00
- SKU:
- 10-5713
- Additional Names:
- Lac-Phe|N-lactoyl-phenylalanine
- Physical State:
- Solid
- Molecular Weight:
- 237.26
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 183241-73-8
- Extra Details:
- Exercise is associated with transient suppression of appetite which previously has been attributed to induction of appetite-regulatory hormone such as GLP-11 or the increase in circulating metabolites including L-lactate2. A targeted metabolomics approach with blood samples from two independent human exercise studies resulted in the identification of N-lactoyl-phenylalanine (Lac-Phe; 183241-73-8) as a highly upregulated circulating metabolite following exercise.3 Lac-Phe was shown, using pharmacological and genetic methods, to be an exercise-inducible metabolite that suppresses feeding and obesity. A single injection of Lac-Phe was demonstrated to reduce food intake by ~50% in diet-induced obese mice. However, Lac-Phe is completely inactive when administered orally.4
- Shipping Conditions:
- Ambient