10-5705
SU9516
Size
£173.00
- SKU:
- 10-5705
- Physical State:
- Solid
- Molecular Weight:
- 241.25
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 377090-84-1
- Immunogen:
- Kinase
- Extra Details:
- Cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 uM for cdk2, cdk1, cdk4, cdk9 respectively.1,2 Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis.3 Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death.4 Inhibits epithelial-mesenchymal transition (IC50=1.21 uM) a crucial pathological event in tumor cell budding and metastasis.5 Cell permeable.
- Shipping Conditions:
- Ambient