10-5574
L6H21
Size
£153.00
- SKU:
- 10-5574
- Physical State:
- Solid
- Molecular Weight:
- 298.34
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 24533-47-9
- Immunogen:
- Inflammasome
- Extra Details:
- L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 uM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFA Alpha and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.
- Shipping Conditions:
- Ambient