10-5571
TPCA-1
Size
£168.00
- SKU:
- 10-5571
- Physical State:
- Solid
- Molecular Weight:
- 229.29
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 507475-17-4
- Immunogen:
- Inflammasome|Kinase|Transcription factor
- Extra Details:
- Selective inhibitor of IK KappaB kinase 2 (IKK2) (IC50 = 17.9 nM).1 Inhibits production of pro-inflammatory cytokines in arthritis and other animal models of inflammation.1,2 Also attenuates NLRP3 inflammasome activation in THP-1 myeloid cells, and suppresses IL1B Beta-induced proliferation, migration, and invasion of HeLa cells.3,4 Continuous exposure to TPCA-1 promotes expansion of hematopoietic stem/progenitor cells (HSPCs) via improved glycolysis and limited ROS production.5
- Shipping Conditions:
- Ambient