10-5515
AR7
Size
£168.00
- SKU:
- 10-5515
- Physical State:
- Solid
- Molecular Weight:
- 257.72
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 80306-38-3
- Immunogen:
- Retinoid receptor and related|Transcription factor
- Extra Details:
- Atypical retinoid which acts as an RARA Alpha antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson's disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
- Shipping Conditions:
- Ambient