10-5322
Tepotinib
Size
£158.00
- SKU:
- 10-5322
- Additional Names:
- EMD-1214063
- Physical State:
- Solid
- Molecular Weight:
- 492.58
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1100598-32-0
- Immunogen:
- Kinase
- Extra Details:
- Tepotinib is a selective type 1b MET inhibitor. In biochemical assays using His6-tagged recombinant human MET kinase domain, tepotinib inhibited kinase activity in a concentration-dependent manner with IC50=1.8 nM.1 It displays marked antitumor activity in MET-dependent tumor models.2 It crosses the blood-brain barrier and displays intracranial antitumor activity.3 Tepotinib can overcome EGFR inhibitor resistance mediated by aberrant c-Met activation4 and is in clinical use for non-small cell lung cancer harboring MET exon 14 skipping alterations.
- Shipping Conditions:
- Ambient