10-5280
ML401
Size
£182.00
- SKU:
- 10-5280
- Additional Names:
- CID73169083|SID 173333998
- Physical State:
- Solid
- Molecular Weight:
- 419.75
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1597489-14-9
- Immunogen:
- GPCR
- Extra Details:
- ML401 is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited 7A Alpha,25-dihydroxycholesterol-induced RS11846 cell chemotaxis, IC50=6 nM.1 GPR183 is a key chemotactic receptor guiding B cell localization to appropriate microenvironments for activation and differentiation.2 It also regulates the homeostasis, localization and immunological function of splenic dendritic cells.3 Oxysterols have been shown to be endogenous ligands for GPR183 with 7A Alpha,25-dihydroxycholesterol being the most potent (Kd=450 pM).4
- Shipping Conditions:
- Ambient