10-5258
Phenylhexyl isothiocyanate
Size
£149.00
- SKU:
- 10-5258
- Additional Names:
- PHI|PHITC
- Physical State:
- liquid
- Molecular Weight:
- 219.35
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 133920-06-6
- Immunogen:
- Acetyltransferase|DNA methyltransferase|Protein methyltransferase
- Extra Details:
- Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents.1 PHITC was the most potent in a series of synthetic arylalkyl isothiocyanates at inhibition of tumorigenicity by NNK, a tobacco-derived nitrosamine, in a mouse model.2 It was also found to induce apoptosis and inhibit leukemia cell growth in vivo3 and was shown to have dual function as a histone deacetylase inhibitor and hypomethylating agent4. PHITC was also shown to restore the activity of mutant p53 and reactivate the p53 pathway in human myeloid leukemia M2 cells.5
- Shipping Conditions:
- Ambient