OSS-128167

Size

£163.00

SKU:: 10-5197
Physical State:: Solid
Molecular Weight:: 366.66
Purity:: >98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 887686-02-4
Immunogen:: Protein deacetylase
Extra Details:: OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 uM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 uM, respectively).1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5