10-5103
AS-1949490
Size
£160.00
- SKU:
- 10-5103
- Physical State:
- Solid
- Molecular Weight:
- 371.88
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1203680-76-5
- Immunogen:
- Phosphatase
- Extra Details:
- A potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2), IC50 = 0.62 M.1 Displays ca. 30-fold selectivity for SHIP2 over SHIP1. Activates insulin signaling via the Akt pathway in liver and lowers glucose levels in diabetic mice.1,2 Enhances BDNF expression in cultured cortical neurons.3 Ameliorates ROS generation but aggravates apoptosis in CD2AP-deficient mouse podocytes.4
- Shipping Conditions:
- Ambient