10-5090
MZ1
Size
£158.00
- SKU:
- 10-5090
- Physical State:
- Solid
- Molecular Weight:
- 1002.64
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1797406-69-9
- Immunogen:
- Bromodomain|PROTAC®
- Extra Details:
- MZ1 consists of JQ1 tethered to a ligand for the E3 ubiquitin ligase VHL and is a selective degrader of the BET bromodomain protein BRD4. It rapidly and potently induces reversible, long-lasting and unexpectedly selective degradation of BRD4 over BRD2 and BRD3.1 It exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B.2 An important tool for studying the effects of BRD4 degradation in cancer therapy.3
- Shipping Conditions:
- Ambient