10-5087
Boceprevir
Size
£168.00
- SKU:
- 10-5087
- Additional Names:
- SCH 503034
- Physical State:
- Solid
- Molecular Weight:
- 519.68
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 394730-60-0
- Immunogen:
- Cytochrome/MDR|Protease
- Extra Details:
- Boceprevir (394730-60-0) directly inhibits Hepatitis C virus (HCV) NS3 protease (overall binding constant for formation of covalent adduct, Ki* = 14 nM; initial inhibition constant Ki = 7.8 uM). This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly. This reversible, slow-binding ketoamide also restores host interferon signaling obstructed by HCV, thus reactivating the immune response1. Recently, it was also found to inhibit the key SARS-CoV-2 protease, Mpro (3CLpro) in vitro (Ki = 1.18 uM) and in cells (EC50 = 1.9 uM, virus-induced cytopathic effects (CPE)
- Shipping Conditions:
- Ambient