10-5056
ICRF-193
Size
£221.00
- SKU:
- 10-5056
- Physical State:
- Solid
- Molecular Weight:
- 282.3
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 21416-88-6
- Immunogen:
- DNA|Topoisomerase
- Extra Details:
- ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1B Beta secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
- Shipping Conditions:
- Ambient