10-5001
STING Degrader 1
Size
£206.00
- SKU:
- 10-5001
- Additional Names:
- SP23
- Physical State:
- Yellow to beige solid
- Molecular Weight:
- 699.68
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2762552-74-7
- Immunogen:
- PROTAC®|STING
- Extra Details:
- STING degrader 1 (2762552-74-7) is a CRBN-based PROTAC degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the Stimulator of Interferon Genes (STING). This degrader was designed by coupling C-170, a small molecule STING inhibitor with pomalidomide via a C-6 linker. It selectively degrades STING with a DC50=3.2 uM.1 It displays antiinflammatory activity in a cisplatin-induced acute kidney injury mouse model.1
- Shipping Conditions:
- Ambient