10-4985
ML792
Size
£192.00
- SKU:
- 10-4985
- Physical State:
- Solid
- Molecular Weight:
- 551.42
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1644342-14-2
- Immunogen:
- Ubiquitin ligase
- Extra Details:
- ML792 is a potent (IC50's = 3 nM SUMO1; 11 nM SUMO2) and selective( IC50 = 32 uM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2
- Shipping Conditions:
- Ambient