C2230

Size

£158.00

SKU:: 10-4955
Physical State:: White to off-white waxy solid
Molecular Weight:: 321.46
Purity:: >98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 882243-88-1
Immunogen:: Ion channel
Extra Details:: C2230 is a novel Cav2.2 channel blocker (IC50 = 1.3 uM @ -50 mV; 10.2 uM @ -80 mV) with a unique binding mode (no GPCR-mediated inhibition). It displays preferential binding to the inactive state of the channel. C2230 is active in both rat and human DRG neurons. Active in rat models of neuropathic pain and mouse models of osteoarthritis. C2230 does not affect somatosensation or motor and cardiac function.