10-4951
Dp44mT
Size
£134.00
- SKU:
- 10-4951
- Additional Names:
- di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone
- Physical State:
- Solid
- Molecular Weight:
- 285.37
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 152095-12-0
- Immunogen:
- Chelator
- Extra Details:
- Dp44mT is a metal chelator with potent antitumor activity.1,2 It displayed an average IC50 of 30 nM over 28 cancer cell lines (IC50 range was 5 nM to 400 nM).2 Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50 = 12 nM for both lines.2 The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage.3,4 It also inhibited T-cell activation and prevented CD25 up-regulation via a copper-dependent mechanism.5
- Shipping Conditions:
- Ambient